Prodynorphin: Difference between revisions

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==Evolutionary implications==
Most humans have multiple copies of the regulatory gene sequence for prodynorphin, which is virtually identical among all primates, whereas other [[primate]]s have only a single copy. In addition, most [[Asia]]n populations have two copies of the gene sequence for prodynorphin, whereas [[East Africa]]s, [[Middle East]]erners, and [[Europe]]ans tend to have three repetitions.<ref name="bmcpsychiatry" >{{Citationcite web |url= https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-019-2272-7 needed|date= 11 September 2019 |title= Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis |author= AugustChang-wang 2014}}Wang
|author2= Min Ma |author3= Wei-guang Lu |author4= Ru-qin Luo |journal= BMC Psychiatry |volume= 19 |issue= 281 }}</ref>
 
The extent of regulatory gene disparities for prodynorphin, between human and primates, has gained the attention of scientists. There are very few genes known to be directly related to mankind's [[speciation]] from other great apes. According to computational biologist researcher Matthew W. Hahn of [[Indiana University (Bloomington)|Indiana University]], "this is the first documented instance of a neural gene that has had its regulation shaped by natural selection during [[human evolution|human origins]]."{{Citation needed|date = August 2014}}