Deuterium: Difference between revisions

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A deuterated drug is a [[small molecule]] medicinal product in which one or more of the [[hydrogen]] atoms contained in the drug molecule have been replaced by deuterium. Because of the [[kinetic isotope effect]], deuterium-containing drugs may have significantly lower rates of [[metabolism]], and hence a longer [[biological half-life|half-life]].<ref name="pmid19295573">{{cite journal |vauthors=Sanderson K |title=Big interest in heavy drugs |journal=Nature |volume=458 |issue=7236 |pages=269 |date=March 2009 |pmid=19295573 |doi=10.1038/458269a}}</ref><ref name="pmid23744136">{{cite journal |vauthors=Katsnelson, A |title=Heavy drugs draw heavy interest from pharma backers |journal=Nature Medicine |volume=19 |issue=6 |pages=656 |date=June 2013 |pmid=23744136 |doi=10.1038/nm0613-656}}</ref><ref name="pmid24294889">{{cite journal |vauthors=Gant, TG |title=Using deuterium in drug discovery: leaving the label in the drug |journal=Journal of Medicinal Chemistry |volume=57 |issue=9 |pages=3595–3611 |date=May 2014 |pmid=24294889 |doi=10.1021/jm4007998}}</ref> In 2017, [[deutetrabenazine]] became the first deuterated drug to receive FDA approval.<ref>{{cite journal |last1=Schmidt |first1=Charles |date=10 July 2017 |title=First deuterated drug approved |journal=[[Nature Biotechnology]] |doi=10.1038/nbt0617-493 |pmid=28591114 |volume=35 |issue=6 |pages=493–494}}</ref>
===Medical imaging===
Wei Min, Ph.D., Professor, Department of Chemistry, Columbia University has developed cellular imaging technique that visualizes the metabolic dynamics as glucose is used to make downstream molecules, such as DNA, protein, lipids, and glycogen to move medical techniques closer to identifying early changes in cells that lead to disease.<ref></ref>
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