Revision as of 17:53, 29 November 2017 (edit) 2405:205:422a:10c7::13ad:48a4 (talk) (→‎Arsenate poisoning) Tags: Mobile edit Mobile web edit ← Previous edit		Revision as of 19:14, 4 February 2018 (edit) (undo) DocTox (talk \| contribs) (→‎Arsenate poisoning: Adding MOA) Next edit →
Arsenate can replace inorganic [[phosphate]] in the step of [[glycolysis]] that produces [[1,3-bisphosphoglycerate]] from [[glyceraldehyde 3-phosphate]]. This yields [[1-arseno-3-phosphoglycerate]] instead, which is unstable and quickly hydrolyzes, forming the next intermediate in the pathway, [[3-phosphoglycerate]]. Therefore, glycolysis proceeds, but the [[Adenosine triphosphate\|ATP]] molecule that would be generated from [[1,3-bisphosphoglycerate]] is lost – arsenate is an uncoupler of glycolysis, explaining its toxicity.<ref>{{cite journal\|last=Hughes \|first=Michael F. \|title=Arsenic toxicity and potential mechanisms of action \|journal=[[Toxicology Letters]] \|year=2002 \|issue=133 \|pages=4 \|url=http://nature.berkeley.edu/departments/nut/undergrad_class/Spr_2003_NST_120/D50.pdf }}{{dead link\|date=July 2017 \|bot=InternetArchiveBot \|fix-attempted=yes }}</ref> As with other arsenic compounds, arsenite ~~can~~binds ~~also~~to ~~inhibit~~[[lipoic acid]],<ref>http://www.med.unc.edu/intselect/files/biochemistry-of-arsenic-poisoning</ref> inhibiting the conversion of [[pyruvate]] into [[acetyl-CoA]], blocking the [[Krebs cycle]] and therefore resulting in further loss of ATP.<ref>{{citation\|title=Arsenic Toxicity Case Study\|author1=Kim Gehle\|author2=Selene Chou\|author3=William S. Beckett\|publisher=Agency for Toxic Substances and Disease Registry\|url=http://www.atsdr.cdc.gov/csem/csem.asp?csem=1&po=0\|date=2009-10-01}}</ref> ==Bacteria using and generating arsenate==

Arsenate: Difference between revisions

Arsenate (edit)

Revision as of 19:14, 4 February 2018