Ansamycin: Difference between revisions

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==Structure==
They are named ansamycins (from the Latin '''ansa''', ''handle'') because of their unique structure, which comprisesconsists of an aromatic moiety bridged by an aliphatic chain.<ref>{{cite journal |author1=Prelog, V. |author2=Oppolzer, W. |journal=Helv. Chim. Acta |title=Rifamycins. 4. Ansamycins, a novel class of microbial metabolism products |volume=56 |pages=2279 |year=1973}}</ref> The main difference between various derivatives of ansamycins is the aromatic moiety, which can be a [[naphthalene]] ring or a [[naphthoquinone]] ring as in [[rifamycin]] and the [[naphthomycin]]s.<ref>{{cite journal |author1=Balerna, M. |author2=Keller-Schierlein, W. |author3=Martius, C. |author4=Wolf, H. |author5=Zähner, H. |journal=Arch. Mikrobiol. |title=Metabolic products of microorganisms. 72. Naphthomycin, an antimetabolite of vitamin K |volume=65 |pages=303–17 |year=1969 |pmid=4988744 |issue=4 |doi=10.1007/bf00412210}}</ref> Another variation comprisesconsists of benzene or a benzoquinone ring system as in [[geldanamycin]] or [[ansamitocin]]. Ansamycins were first discovered in 1959 by Sensi et al. from ''[[Amycolatopsis]] mediterranei'', an [[actinomycete]] bacterium.<ref>{{cite journal |author1=Sensi, P. |author2=Margalith, P. |author3=Timbal, M. T. |journal=Ed. Sci. |title=Rifomycin, a new antibiotic; preliminary report |volume=14 |pages=146 |year=1959}}</ref>
 
==Examples==