Arsenate: Difference between revisions

4 bytes added ,  7 years ago
(leading zeroes not normally used with dates (WP:DATESNO); tidy)
== Arsenate poisoning ==
Arsenate can replace inorganic [[phosphate]] in the step of [[glycolysis]] that produces [[1,3-bisphosphoglycerate]] from [[glyceraldehyde 3-phosphate]]. This yields [[1-arseno-3-phosphoglycerate]] instead, which is unstable and quickly hydrolyzes, forming the next intermediate in the pathway, [[3-phosphoglycerate]]. Therefore glycolysis proceeds, but the [[Adenosine triphosphate|ATP]] molecule that would be generated from [[1,3-bisphosphoglycerate]] is lost - arsenate is an uncoupler of glycolysis, explaining its toxicity.<ref>{{cite journal|last=Hughes|first=Michael F.|title=Arsenic toxicity and potential mechanisms of action|journal=[[Toxicology Letters]]|year=2002|issue=133|pages=4|url=}}</ref>
As with other arsenic compounds, arsenate can also inhibit the conversion of [[pyruvate]] into [[acetyl-CoA]], blocking the [[Krebs cycle]] and therefore resulting in further loss of ATP.<ref>{{citation|title=Arsenic Toxicity Case Study|author1=Kim Gehle|author2=Selene Chou|author3=William S. Beckett|publisher=Agency for Toxic Substances and Disease Registry|url=|date=2009-10-01}}</ref>