Ansamycin: Difference between revisions

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==Structure==
They are named ansamycins—''ansa'' from the Latin for handle—because of their unique structure which comprises an aromatic moiety bridged by an aliphatic chain <ref>{{cite journal |author=Prelog, V.; Oppolzer, W. |journal=Helv. Chim. Acta. |title=Rifamycins. 4. Ansamycins, a novel class of microbial metabolism products |volume=56 |pages=2279 |year=1973}}</ref>. The main difference between various derivatives of ansamycins is the aromatic moiety, which can be a [[naphthalene ring]] or a [[naphthoquinone ring]] as in [[rifamycin]] and [[naphthomycin]] <ref>{{cite journal |author=Balerna, M.; Keller-Schierlein, W.; Martius, C.; Wolf, H.; Zähner, H. |journal=Arch. Mikrobiol. |title=Metabolic products of microorganisms. 72. Naphthomycin, an antimetabolite of vitamin K |volume=65 |pages=303 |year=1969}}</ref>.
Another variation comprises benzene or a benzoquinone ring system as in geldanamycin or ansamitocin. Ansamycins were first discovered in 1959 by Sensi et al from ''Amycolatopsis mediterranei'', an Actinomycete.<ref>{{cite journal |author=Sensi, P.; Margalith, P.; Timbal, M. T. |journal=Ed. Sci. |title=Rifomycin, a new antibiotic; preliminary report |volume=14 |pages=146 |year=1959}}</ref>
 
==Examples==