Ansamycin: Difference between revisions

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Another variation comprises of benzene or a benzoquinone ring system as in geldanamycin or ansamitocin. Ansamycins were first discovered in 1959 by Sensi et al from ''Amycolatopsis mediterranei'', an Actinomycete.<ref>{{cite journal |author=Sensi, P.; Margalith, P.; Timbal, M. T. |journal=Ed. Sci. |title=Rifomycin, a new antibiotic; preliminary report |volume=14 |pages=146 |year=1959}}</ref> Rifamycins are a subclass of ansamycins with high potency against mycobacterial activity. This resulted in their wide use in the treatment of tuberculosis, leprosy, and AIDS-related mycobacterial infections.<ref>{{cite journal |author=Floss, H. G.; Yu, T. |journal=Curr. Opin. Chem. Biol. |title=Lessons from the rifamycin biosynthetic gene cluster |volume=3 |pages=592 |year=1999}}</ref> Since then various analogues have been isolated from other prokaryotes.
 
[[Image:http://metaupload.wikimedia.org/wikiwikipedia/commons/0/00/Image:Rifamycin_B.gif|Structure of Rifamycin B]]
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Image:http://meta.wikimedia.org/wiki/Image:Rifamycin_sv.gif|Structure of Rifamycin SV
Image:http://meta.wikimedia.org/wiki/Image:Rifamycin_B.gif|Structure of Rifamycin B
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== References ==
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