Linoleic acid is a chemical compound wih formula C
2, specifically the fatty acid with structure HO(O=)C–(CH2)7CH=CH–CH2–CH=CH–(CH2–)3H with both double bonds (between carbon atoms 9 and 10, and 12 and 13) in the cis configuration. It is often denoted in technical food science literature by the shorthand 18:2 (n-6) or 18:2 cis-9,12. A linoleate is a salt or ester of this acid.
C18:2 (Lipid numbers)
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||280.452 g·mol−1|
|Melting point||−12 °C (10 °F)|
−6.9 °C (19.6 °F)
−5 °C (23 °F)
|Boiling point||229 °C (444 °F) at 16 mmHg|
230 °C (446 °F) at 21 mbar
230 °C (446 °F) at 16 mmHg
|Vapor pressure||16 Torr at 229 °C|
|NFPA 704 (fire diamond)|
|Flash point||112 °C (234 °F)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Linoleic acid is a polyunsaturated omega-6 fatty acid. It is a colorless or white oil that is virtually insoluble in water but very soluble in acetone, benzene, diethyl ether and ethanol.. It typically occurs in nature as a triglyceride (ester of glycerin) rather than as a free fatty acid. It is one of two essential fatty acids for humans, who must obtain it through their diet.
In 1844, F. Sacc, working at the laboratory of Justus von Liebig, isolated linoleic acid from linseed oil. In 1886, K. Peters determined the existence of two double bonds.. Its essential role in human diet was discovered by G. O. Burr and others in 1930. Its chemical structure was determined by T.P. Hilditch and others in 1939, and it was synthesized by R. A. Raphael and F. Sondheimer in 1950.
Linoleic acid is a polyunsaturated fatty acid used in the biosynthesis of arachidonic acid (AA) with elongation and saturation,  and thus some prostaglandins, leukotrienes (LTA, LTB, LTC), and thromboxane (TXA). It is found in the lipids of cell membranes. It is abundant in safflower, sunflower, corn, and comprises over half their composition by weight. It is present in medium quantities in soybean oils, sesame, and almonds.
The consumption of linoleic acid is vital to proper health, as it is an essential fatty acid. In rats, a diet deficient in linoleate (the salt form of the acid) has been shown to cause mild skin scaling, hair loss, and poor wound healing. However, chronic consumption of high levels of LA may be associated with the development of ulcerative colitis.[verification needed]
Cockroaches release oleic and linoleic acid upon death, which discourages other roaches from entering the area. This is similar to the mechanism found in ants and bees, which release oleic acid upon death.
Metabolism and eicosanoidsEdit
There is evidence suggesting that infants lack Δ6desaturase of their own, and must acquire it through breast milk. Studies show that breast-milk fed babies have higher concentrations of GLA than formula-fed babies, while formula-fed babies have elevated concentrations of LA.
GLA is converted to dihomo-γ-linolenic acid (DGLA), which in turn is converted to arachidonic acid (AA). One of the possible fates of AA is to be transformed into a group of metabolites called eicosanoids during the inflammatory response and during physical activity; eicosanoids are a class of paracrine hormones. The three types of eicosanoids are prostaglandins, thromboxanes, and leukotrienes. Eicosanoids produced from AA tend to promote (not cause) inflammation and promote growth during and after physical activity in healthy humans. For example, both AA-derived thrombaxane and leukotrieneB4 are proaggregatory and vasoconstrictive eicosanoids during inflammation. The oxidized metabolic products of linoleic acid, such as 9-hydroxyoctadecanoic acid and 13-hydroxyoctadecanoic acid, have also been shown to activate TRPV1, the capsaicin receptor, and through this might play a major role in hyperalgesia and allodynia.
There are some suggested negative health effects related to this inflammation promoting function of linoleic acid as an omega-6 fatty acid.
LA is also converted by various lipoxygenases, cyclooxygenases, certain cytochrome P450 enzymes (the CYP monooxygenases), and non-enzymatic autoxidation mechanisms to mono-hydroxyl products viz., 13-Hydroxyoctadecadienoic acid, and 9-Hydroxyoctadecadienoic acid; these two hydroxy metabolites are enzymatically oxidized to their keto metabolites, 13-oxo-octadecadienoic acid and 9-oxo-octadecdienoic acid. Certain cytochrome P450 enzymes, the CYP epoxygenases, metabolize LA to epoxide products viz., its 12,13-epoxide, Vernolic acid, and its 9,10-epoxide, Coronaric acid. All of these linoleic acid products have bioactivity and are implicated in human physiology and pathology.
Linoleic acid is used in making quick-drying oils, which are useful in oil paints and varnishes. These applications exploit the easy reaction of the linoleic acid with oxygen in air, which leads to crosslinking and formation of a stable film called linoxyn.
Linoleic acid has become increasingly popular in the beauty products industry because of its beneficial properties on the skin. Research points to linoleic acid's anti-inflammatory, acne reductive, skin-lightening and moisture retentive properties when applied topically on the skin.
Use in researchEdit
Linoleic acid lipid radicals can be used to show the antioxidant effect of polyphenols and natural phenols. Experiments on linoleic acid subjected to 2,2'-Azobis(2-amidinopropane) dihydrochloride induced oxidation of linoleic acid, thus producing lipid radicals; the use of different combinations of phenolics then show that binary mixtures can lead to either a synergetic antioxidant effect, or to an antagonistic effect towards the lipid radicals. Research like this is useful in discovering which phenols prevent the autoxidation of lipids in vegetable oils.
|Evening Primrose oil||65-80%|||
|Melon seed oil||70%|
|Grape seed oil||69.6%|
|Prickly Pear seed oil||62.3%|
|Barbary Fig seed oil||65%|
|Wheat germ oil||55%|
|Rice bran oil||39%|
|Linseed oil (flax)||15%|
|Olive oil||10% (3.5 - 21%)|||
- The Merck Index, 11th Edition, 5382
- William M. Haynes (2016). CRC Handbook of Chemistry and Physics (97th ed.). Boca Raton: CRC Press. p. 3–338. ISBN 978-1-4987-5429-3.
- Record of CAS RN 60-33-3 in the GESTIS Substance Database of the Institute for Occupational Safety and Health
- Mattes, RD (2009). "Is there a fatty acid taste?". Annu. Rev. Nutr. 29: 305–27. doi:10.1146/annurev-nutr-080508-141108. PMC 2843518. PMID 19400700.
- Simopoulos, Artemis P. (2008). "The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases". Experimental Biology and Medicine. 233 (6): 674–688. doi:10.3181/0711-mr-311. PMID 18408140.
- F. Sacc (1844) "Ueber das Leinöl, seine physicalischen und chemischen Eigenscharften und seine Oxydationsproducte". Liebig Annalen, volume 51, pages 213-230.
- F. Sacc (1845): "Expériences sur les propriétés physiques et chimiques de l'huile de Lin". SChweizer. Gesell. N. Dekschr., volume 7
- (1886), Monatsch., volume 7, pages 522-
- (1930: J Biol Chem, volume 86, pages 587-
- R. A. Raphael and Franz Sondheimer (1950): "The synthesis of long-chain aliphatic acids from acetylenic compounds. Part III. The synthesis of linoleic acid". Journal of the Chemical Society (Resumed), article 432, doi:10.1039/jr9500002100
- Whelan J, Fritsche K. (2013). "Linoleic acid". Adv Nutr. 4 (3): 311–312. doi:10.3945/an.113.003772. PMC 3650500. PMID 23674797.CS1 maint: uses authors parameter (link)
- "Nutrient Data Laboratory Home Page". USDA National Nutrient Database for Standard Reference, Release 20. U.S. Department of Agriculture, Agricultural Research Service. 2007. Archived from the original on 14 April 2016.
- Kaur, Narinder; Chugh, Vishal; Gupta, Anil K. (October 2014). "Essential fatty acids as functional components of foods- a review". Journal of Food Science and Technology. 51 (10): 2289–2303. doi:10.1007/s13197-012-0677-0. PMC 4190204.
- Whelan, Jay; Fritsche, Kevin (May 2013). "Linoleic Acid". Advances in Nutrition. 4 (3): 311–312. doi:10.3945/an.113.003772. PMC 3650500. PMID 23674797.
- Cunnane S, Anderson M (1 April 1997). "Pure linoleate deficiency in the rat: influence on growth, accumulation of n-6 polyunsaturates, and (1-14C) linoleate oxidation". J Lipid Res. 38 (4): 805–12. PMID 9144095. Retrieved 15 January 2007.
- Ruthig DJ, Meckling-Gill KA (1 October 1999). "Both (n-3) and (n-6) fatty acids stimulate wound healing in the rat intestinal epithelial cell line, IEC-6". Journal of Nutrition. 129 (10): 1791–8. doi:10.1093/jn/129.10.1791. PMID 10498749.
- "Role of Fats in Ulcerative Colitis | Gastrointestinal Society". www.badgut.org. Retrieved 9 January 2018.
- "Earth News: Ancient 'smell of death' revealed". BBC. 9 September 2009.
- David F. Horrobin (1993). "Fatty acid metabolism in health and disease: the role of Δ-6-desaturase". American Journal of Clinical Nutrition. 57 (5 Suppl): 732S–7S. doi:10.1093/ajcn/57.5.732S. PMID 8386433.
- Piomelli, Daniele (2000). "Arachidonic Acid". Neuropsychopharmacology: The Fifth Generation of Progress. Archived from the original on 15 July 2006. Retrieved 16 April 2009.
- Patwardhan, AM; Scotland, PE; Akopian, AN; Hargreaves, KM (2009). "Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia". Proceedings of the National Academy of Sciences of the United States of America. 106 (44): 18820–4. Bibcode:2009PNAS..10618820P. doi:10.1073/pnas.0905415106. PMC 2764734. PMID 19843694.
- Diezel, W.E.; Schulz, E.; Skanks, M.; Heise, H. (1993). "Plant oils: Topical application and anti-inflammatory effects (croton oil test)". Dermatologische Monatsschrift. 179: 173.
- Letawe, C; Boone, M; Pierard, GE (March 1998). "Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones". Clinical and Experimental Dermatology. 23 (2): 56–58. doi:10.1046/j.1365-2230.1998.00315.x. PMID 9692305.
- Ando, H; Ryu, A; Hashimoto, A; Oka, M; Ichihashi, M (March 1998). "Linoleic acid and α-linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin". Archives of Dermatological Research. 290 (7): 375–381. doi:10.1007/s004030050320. PMID 9749992.
- Darmstadt, GL; Mao-Qiang, M; Chi, E; Saha, SK; Ziboh, VA; Black, RE; Santosham, M; Elias, PM (2002). "Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries". Acta Paediatrica. 91 (5): 546–554. CiteSeerX 10.1.1.475.1064. doi:10.1080/080352502753711678. PMID 12113324.
- Peyrat-Maillard, M. N.; Cuvelier, M. E.; Berset, C. (2003). "Antioxidant activity of phenolic compounds in 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced oxidation: Synergistic and antagonistic effects". Journal of the American Oil Chemists' Society. 80 (10): 1007–1012. doi:10.1007/s11746-003-0812-z.
- "Evening Primrose Oil for Menopause does it help". 26 January 2018.
- Oomah, B. Dave; Busson, Muriel; Godfrey, David V; Drover, John C. G (1 January 2002). "Characteristics of hemp (Cannabis sativa L.) seed oil". Food Chemistry. 76 (1): 33–43. doi:10.1016/S0308-8146(01)00245-X.
- Oil, peanut, salad or cooking: search for peanut oil on "USDA Food Composition Databases". Archived from the original on 3 March 2015. Retrieved 16 September 2009.
- Wu, Hao; Shi, John; Xue, Sophia; Kakuda, Yukio; Wang, Dongfeng; Jiang, Yueming; Ye, Xingqian; Li, Yanjun; Subramanian, Jayasankar (2011). "Essential oil extracted from peach (Prunus persica) kernel and its physicochemical and antioxidant properties". LWT - Food Science and Technology. 44 (10): 2032–2039. doi:10.1016/j.lwt.2011.05.012.
- M. K. Nutter, E. E. Lockhart and R. S. Harris (1943). "The chemical composition of depot fats in chickens and turkeys". Journal of the American Oil Chemists' Society. 20 (11): 231–234. doi:10.1007/BF02630880.
- "Olive Oil : Chemical Characteristics".
- Beltran; Del Rio, C; Sánchez, S; Martínez, L (2004). "Influence of Harvest Date and Crop Yield on the Fatty Acid Composition of Virgin Olive Oils from Cv. Picual" (PDF). J. Agric. Food Chem. 52 (11): 3434–3440. doi:10.1021/jf049894n. PMID 15161211.
- Nasaruddin, Mohd hanif; Noor, Noor Qhairul Izzreen Mohd; Mamat, Hasmadi (2013). "Komposisi Proksimat dan Komponen Asid Lemak Durian Kuning (Durio graveolens) Sabah" [Proximate and Fatty Acid Composition of Sabah Yellow Durian (Durio graveolens)] (PDF). Sains Malaysiana (in Malay). 42 (9): 1283–1288. ISSN 0126-6039. OCLC 857479186. Retrieved 28 November 2017.
- "Compound Summary: Linoleic acid". PubChem. U.S. National Library of Medicine.