|Residence||Toronto, Ontario, Canada|
|Education||National Ballet School of Canada|
|Occupation||Ballet dancer, administrator|
|Spouse(s)||Ross Petty (1983–present)|
Kain's mother enrolled her daughter in ballet training because she believed it would improve her postural alignment, poise, and discipline. The family moved from Ancaster to Erindale Woodlands, Toronto Township when Kain was in grade 6 (age 11, 1962) so she could begin training at the National Ballet School of Canada. (The majority of Toronto Township, including Erindale Woodlands, is now Mississauga.) Upon graduating in 1969, she was invited to join the National Ballet of Canada.
Kain became a principal dancer in 1971, performing central roles in a wide array of ballets, eventually becoming well known in Canada, with the help of legendary dancer Rudolf Nureyev. She worked as a guest artist with Roland Petit's Ballet National de Marseilles, the Bolshoi Ballet, the London Festival Ballet, the Paris Opera Ballet, the Hamburg Ballet, the Vienna State Opera Ballet, and the Eliot Feld Ballet. Kain is a subject of The Portraits of Andy Warhol, c. 1980.
In 1977 Kain stopped dancing, but started again in 1981 with the National Ballet of Canada, where she performed for 15 more years. In 1996, Kain reunited with Frank Augustyn to appear in her husband Ross Petty's panto production of Robin Hood at Toronto's Elgin Theatre. Kain retired as a professional dancer in 1997.
In 1998, she returned to the National Ballet of Canada as part of the senior management team, in the role of artistic associate. She supported artistic director James Kudelka against principal dancer Kimberley Glasco in a wrongful-dismissal suit. In 2005, she succeeded Kudelka as artistic director.
In 1976, she became an Officer of the Order of Canada and was made a Companion of the Order of Canada in 1991. She was made a member of the Order of Ontario in 1990. She holds honorary degrees from the University of Toronto, York University, McMaster University, Trent University, and the University of British Columbia. In May 1998, the French Government named her an Officer of the Order of Arts and Letters. Among Kain's other honours are the National Arts Centre Award, a companion award of the Governor General's Performing Arts Awards (1997) and the Governor General's Performing Arts Award for Lifetime Artistic Achievement (2002). In 1996, she became the first Canadian to receive the Cartier Lifetime Achievement Award. The choreographer Marguerite Derricks cited Kain as one of her heroes. in 1989 the Canadian Broadcasting Corporation made a documentary about her, Karen Kain, Prima Ballerina. Kain had an arts based public middle school in Etobicoke named after her (Karen Kain School of the Arts) in 2008. In 2012, Kain received the Queen Elizabeth II Diamond Jubilee Medal.
In 1998 she was inducted into Canada's Walk of Fame.
Kain has been married since 1983 to Ross Petty, a stage and film actor, and producer of theatrical pantomime productions in Canada for over 20 years. Kain's brother, Kevin Kain, is a noted tropical medicine expert based in Toronto, Ontario; she has three younger siblings and two nephews - Dylan and Taylor Kain.
In 1976 Kain appeared in a televised version of the ballet Giselle as the highly coveted title role, alongside Nadia Potts, Frank Augustyn, and Anne Ditchburn. The production was first shown in 1986. In 1985, Kain starred in an episode of the popular Canadian TV series Seeing Things. Kain was also alluded to in the 2003 movie directed by Denys Arcand, "The Barbarian Invasions" when Rémy Girard reminisced about his past love affairs. Kain did a TV commercial for The Art Shoppe, a furniture store in Toronto during the 1970s
- "Karen Kain, Budding Ballerina: Local ballerina ends third year". The Weekly. Port Credit, Ontario. 29 July 1965. Retrieved 21 September 2015.
- https://web.archive.org/web/20081022013614/http://www.collectionscanada.gc.ca/women/002026-603-e.html. Archived from the original on October 22, 2008. Retrieved December 10, 2008. Missing or empty
- Doob, Penelope Reed (4 March 2015). "Karen Kain". The Canadian Encyclopedia (online ed.). Historica Canada. Retrieved 21 September 2015.
- Kain, Karen (1995). Karen Kain: Movement Never Lies : an Autobiography. McClelland & Stewart. ISBN 978-0-7710-4575-2.
- "Karen Kain biography". Governor General's Performing Arts Awards Foundation. Retrieved 3 February 2015.
- Thompson, Bob (July 5, 1999). "A woman on the Go Go: Catchy Gap ad, Austin Powers' movies make choreographer a hot commodity". Kingston Whig-Standard. Kingston, Ontario. p. 27.
- "Karen Kain, Prima Ballerina". CBC News. Canadian Broadcast Corporation. Retrieved 21 September 2015.
- "Diamond Jubilee Gala toasts exceptional Canadians". CBC News. Canadian Broadcast Corporation. 18 June 2012. Retrieved 19 June 2012.