Carolyn Ruth Bertozzi (born October 10, 1966) is an American chemist. At Stanford University, she holds the Anne T. and Robert M. Bass Professorship in the School of Humanities and Sciences.[1] In addition, Bertozzi is an Investigator at the Howard Hughes Medical Institute (HHMI)[2] and is the former Director of the Molecular Foundry, a nanoscience research center at Lawrence Berkeley National Laboratory.[3] She received a MacArthur "genius" award at age 33,[4] making her one of the younger scientists to receive this award.[5] In 2010 she was the first woman to receive the prestigious Lemelson-MIT Prize faculty award. She is a member of the National Academy of Sciences, the National Academy of Inventors, and the Institute of Medicine. In 2014, it was announced that Bertozzi would lead ACS Central Science, the American Chemical Society's first peer-reviewed open access journal that offers all content freely to the public.[6]

Carolyn R. Bertozzi
Carolyn Bertozzi IMG 9384.jpg
Born (1966-10-10) October 10, 1966 (age 52)
Alma materHarvard University
University of California, Berkeley
University of California, San Francisco
Known forbioorthogonal chemistry
AwardsMacArthur Foundation Fellowship (1999)
ACS Award in Pure Chemistry (2001)
Lemelson-MIT Prize (2010)
Heinrich Wieland Prize (2012)
Scientific career
Fieldschemistry
InstitutionsStanford University
University of California, Berkeley
Lawrence Berkeley National Laboratory
University of California, San Francisco
External video
“Carolyn Bertozzi: Chemical Glycobiology”, iBiology

Life and careerEdit

Born in Boston, Massachusetts, Bertozzi received her A.B. summa cum laude in chemistry from Harvard University, where she worked with Professor Joe Grabowski on the design and construction of a photoacoustic calorimeter.[7] While an undergraduate, she played in various bands, including one with future Rage Against the Machine guitarist Tom Morello.[8] After graduating she worked briefly at Bell Labs with Chris Chidsey and at Massachusetts General Hospital. Bertozzi is the daughter of physicist William Bertozzi[9] and the younger sister of UCLA mathematician Andrea Bertozzi.[10]

Bertozzi completed her Ph.D. in Chemistry at UC Berkeley in 1993 with Professor Mark Bednarski, working on the chemical synthesis of oligosaccharide analogs.[11] She then was a postdoctoral fellow at UCSF with Professor Steven Rosen, where she studied the activity of endothelial oligosaccharides in promoting cell adhesion at inflammation sites.[12][13] She was able to modify the protein and sugar molecules in the walls of living cells so that the cells do not reject foreign materials such as medical implants.[14] Bertozzi joined the UC Berkeley faculty in 1996.[12] She has been an investigator with HHMI since 2000.[3] In 2015, Bertozzi moved to Stanford University to join the ChEM-H Institute.[15]

Bertozzi studies the glycobiology underlying diseases such as cancer, inflammatory disorders such as arthritis, and infectious diseases such as tuberculosis. In particular, Bertozzi has advanced understanding of cell surface oligosaccharides involved in cell recognition and inter-cellular communication. Bertozzi is credited for developing the field of bioorthogonal chemistry which employs a bioorthogonal chemical reporters, such as the azide to label biomolecules within living systems. Her lab has also developed tools for research, including chemical tools for studying glycans in living systems and more recently nanotechnologies for probing biological systems.[3][16]

In addition to her academic work, Bertozzi works actively with biotechnology start-ups. She has served on the research advisory board of GlaxoSmithKline, and has a startup of her own, Redwood Bioscience of Emeryville, California.[17] Bertozzi is a cofounder of Palleon Pharma of Waltham, Massachusetts,[18] which is investigating glycoimmune checkpoint inhibitors as a potential treatment for cancer.[19] Several of the technologies developed in her lab have been adapted for commercial use.[which?]

Significant papers and publicationsEdit

  • Mahal, Lara K.; Yarema, Kevin J.; Bertozzi, Carolyn R. (1997). "Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis". Science. 276 (5315): 1125–8. doi:10.1126/science.276.5315.1125. PMID 9173543.
  • Bertozzi, Carolyn R.; Kiessling, Laura L. (2001). "Chemical Glycobiology". Science. 291 (5512): 2357–64. Bibcode:2001Sci...291.2357B. doi:10.1126/science.1059820. PMID 11269316.
  • Saxon, Eliana; Bertozzi, Carolyn R. (2000). "Cell Surface Engineering by a Modified Staudinger Reaction". Science. 287 (5460): 2007–10. Bibcode:2000Sci...287.2007S. doi:10.1126/science.287.5460.2007. PMID 10720325.
  • Prescher, Jennifer A.; Bertozzi, Carolyn R. (2005). "Chemistry in living systems". Nature Chemical Biology. 1 (1): 13–21. doi:10.1038/nchembio0605-13. PMID 16407987.
  • Wang, Peng George; Bertozzi, Carolyn R., eds. (2001). Glycochemistry: Principles, Synthesis, and Applications. New York: Marcel Dekker. ISBN 978-0-8247-0538-1.

Awards and honorsEdit

 
Carolyn Bertozzi, receiving the Emanuel Merck Lectureship in 2011

ReferencesEdit

  1. ^ Adams, Amy. "Stanford chemist explains excitement of chemistry to students, the public". Stanford News. Retrieved 19 July 2015.
  2. ^ "Carolyn Bertozzi honored by GLBT organization". UC Berkeley News. 27 February 2007. Retrieved 8 February 2013.
  3. ^ a b c "Carolyn Bertozzi". HHMI. Retrieved 8 February 2013.
  4. ^ "Carolyn Bertozzi, Organic Chemist". MacArthur Foundation. Retrieved 3 February 2015.
  5. ^ MacFarquhar, Neil (June 23, 1999). "32 Receive Grants From MacArthur Foundation". The New York Times. Retrieved 24 October 2015.
  6. ^ Wang, Linda. "Carolyn Bertozzi To Lead ACS Central Science | Chemical & Engineering News". cen.acs.org. Retrieved 2015-08-19.
  7. ^ Grabowski, Joseph J.; Bertozzi, Carolyn R.; Jacobsen, John R.; Jain, Ahamindra; Marzluff, Elaine M.; Suh, Annie Y. (1992). "Fluorescence probes in biochemistry: An examination of the non-fluorescent behavior of dansylamide by photoacoustic calorimetry". Analytical Biochemistry. 207 (2): 214–26. doi:10.1016/0003-2697(92)90003-P. PMID 1481973.
  8. ^ "Meet Carolyn Bertozzi". NIGMS. Retrieved 8 February 2013.
  9. ^ "MIT Physics Department Faculty". Retrieved 4 June 2012.
  10. ^ "UCLA Math Department Faculty". Retrieved 4 June 2012.
  11. ^ "Bertozzi: Infectious In Her Enthusiasm". Chemical & Engineering News. 78 (5): 26–35. January 31, 2000.
  12. ^ a b Davis, T. (16 February 2010). "Profile of Carolyn Bertozzi". Proceedings of the National Academy of Sciences. 107 (7): 2737–2739. Bibcode:2010PNAS..107.2737D. doi:10.1073/pnas.0914469107. PMC 2840349. PMID 20160128.
  13. ^ Gardiner, Mary Beth (2005). "The Right Chemistry" (PDF). HHMI Bulletin. Winter 2005: 8–12. Retrieved 24 October 2015.
  14. ^ "Carolyn Bertozzi". Chemical Heritage Foundation. Archived from the original on July 12, 2016.
  15. ^ "Carolyn R. Bertozzi". bertozzigroup.stanford.edu. Retrieved 2018-04-13.
  16. ^ a b "Carolyn Bertozzi 2010 Lemelson-MIT Prize". MIT. Retrieved 13 May 2014.
  17. ^ McCook, Alison (March 6, 2013). "Women in Biotechnology: Barred from the Boardroom". Scientific American. Retrieved 24 October 2015.
  18. ^ Palleon Pharma - Leadership
  19. ^ MassBio - Palleon Pharma
  20. ^ "Carolyn R. Bertozzi". Arnold and Mabel Beckman Foundation. Retrieved 1 August 2018.
  21. ^ "President Honors Outstanding Young Scientists". clintonwhitehouse4.archives.gov. Retrieved 2019-09-07.
  22. ^ "Book of Members, 1780–2010: Chapter B" (PDF). American Academy of Arts and Sciences. Retrieved June 24, 2011.
  23. ^ "05.03.2005 - Three UC Berkeley faculty named to National Academy of Sciences". www.berkeley.edu. Retrieved 2019-09-07.
  24. ^ Cassell, Heather (February 22, 2007). "Two Bay Area gay scientists honored". Bay Area Reporter. Retrieved 24 October 2015.
  25. ^ "NOGLSTP to Honor Bertozzi, Gill, Mauzey, and Bannochie at 2007 Awards Ceremony in February". NOGLSTP. Retrieved 2019-02-19.
  26. ^ Kamerling, Johannis P. (2008-03-01). "The Roy L. Whistler International Award in Carbohydrate Chemistry 2008". Glycobiology. 18 (3): 209–209. doi:10.1093/glycob/cwn005. ISSN 0959-6658.
  27. ^ "List of Members". www.leopoldina.org. Retrieved 8 October 2017.
  28. ^ "Carolyn Bertozzi Wins Harrison Howe Award | February 23, 2009 Issue - Vol. 87 Issue 8 | Chemical & Engineering News". cen.acs.org. Retrieved 2019-09-07.
  29. ^ Affairs, Public; October 17, UC Berkeley|; 2011July 9; 2015 (-001-11-30T00:00:00+00:00). "Two UC Berkeley faculty named to Institute of Medicine". Berkeley News. Retrieved 2019-09-07. Check date values in: |date= (help)
  30. ^ "Bioorganic & Medicinal Chemistry Letters | Tetrahedron Young Investigator Award 2011: Carolyn R. Bertozzi | ScienceDirect.com". www.sciencedirect.com. Retrieved 2019-09-07.
  31. ^ "Simmons among nine honorary degree recipients". Brown University. 16 May 2012. Retrieved 28 May 2014.
  32. ^ "Heinrich Wieland Prize 2012 goes to Carolyn R. Bertozzi". Boehringer Ingelheim Foundation. 18 October 2012. Retrieved 30 June 2014.[permanent dead link]
  33. ^ "Carolyn Bertozzi and George Smoot Elected to National Academy of Inventors | Research UC Berkeley". vcresearch.berkeley.edu. Retrieved 2019-09-07.
  34. ^ "Bloemendal Medal". www2.rimls.nl. Retrieved 2019-09-07.
  35. ^ "Arthur C. Cope Awards".
  36. ^ "Distinguished scientists elected as Fellows and Foreign Members of the Royal Society". The Royal Society. 9 May 2018. Retrieved 10 May 2018.

External linksEdit