An anodyne is a drug used to lessen pain through reducing the sensitivity of the brain or nervous system. The term was common in medicine before the 20th century, but such drugs are now more often known as analgesics or painkillers.
Etymologically, the term covers any substance that reduces pain, but the term was used more restrictively by doctors. Some definitions restrict the term to topical medications, including herbal simples such as onion, lily, root of mallows, leaves of violet, and elderberry. Other definitions include ingested narcotics, hypnotics, and opioids. In the 19th century, the primary anodynes were opium, henbane, hemlock, tobacco, nightshade ("stramonium"), and chloroform.
Certain compound medicines were also called by this name, such as anodyne balsam, made of castile soap, camphor, saffron, and spirit of wine, and digested in a sand heat. It was recommended not only for easing extreme pain, but for assisting in discharging the peccant matter that occurred with the pain.
In literary usage, the word has escaped its strictly medical meaning to convey anything "soothing or relaxing" (since the 18th century) or even anything "non-contentious", "blandly agreeable", or unlikely to cause offence or debate.
- Chambers, Ephraim, ed. (1728), "Anodyne", Cyclopædia, James & John Knapton.
- Baynes, T.S., ed. (1878), , Encyclopædia Britannica, 2 (9th ed.), New York: Charles Scribner's Sons, p. 90
- Chisholm, Hugh, ed. (1911), Encyclopædia Britannica, 2 (11th ed.), Cambridge University Press, p. 79 ,
- Quain, Richard (1883), A Dictionary of Medicine: Including General Pathology, General Therapeutics
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