An aneurysm is an outward bulging, likened to a bubble or balloon, caused by a localized, abnormal, weak spot on a blood vessel wall. Aneurysms are a result of a weakened blood vessel wall, and may be a result of a hereditary condition or an acquired disease. Aneurysms can also be a nidus (starting point) for clot formation (thrombosis) and embolization. The word is from Greek: ἀνεύρυσμα, aneurysma, "dilation", from ἀνευρύνειν, aneurynein, "to dilate". As an aneurysm increases in size, the risk of rupture increases, leading to uncontrolled bleeding. Although they may occur in any blood vessel, particularly lethal examples include aneurysms of the Circle of Willis in the brain, aortic aneurysms affecting the thoracic aorta, and abdominal aortic aneurysms. Aneurysms can arise in the heart itself following a heart attack, including both ventricular and atrial septal aneurysms.
|Angiography of an aneurysm in a brain artery. The aneurysm is the large bulge in the center of the image.|
- 1 Classification
- 2 Signs and symptoms
- 3 Risk factors
- 4 Pathophysiology
- 5 Mechanics
- 6 Diagnosis
- 7 Treatment
- 8 Epidemiology
- 9 Notable cases
- 10 References
- 11 External links
Aneurysms are classified by type, morphology, or location.
True and false aneurysmsEdit
A true aneurysm is one that involves all three layers of the wall of an artery (intima, media and adventitia). True aneurysms include atherosclerotic, syphilitic, and congenital aneurysms, as well as ventricular aneurysms that follow transmural myocardial infarctions (aneurysms that involve all layers of the attenuated wall of the heart are also considered true aneurysms).
A false aneurysm, or pseudoaneurysm, is a collection of blood leaking completely out of an artery or vein, but confined next to the vessel by the surrounding tissue. This blood-filled cavity will eventually either thrombose (clot) enough to seal the leak, or rupture out of the surrounding tissue.:357
Pseudoaneurysms can be caused by trauma that punctures the artery, such as knife and bullet wounds, as a result of percutaneous surgical procedures such as coronary angiography or arterial grafting, or use of an artery for injection.
Aneurysms can also be classified by their macroscopic shape and size and are described as either saccular or fusiform. The shape of an aneurysm is not specific for a specific disease.:357 The size of the base or neck is useful in determining the chance of for example endovascular coiling.
Saccular aneurysms are spherical in shape and involve only a portion of the vessel wall; they vary in size from 5 to 20 cm (2.0 to 7.9 in) in diameter, and are often filled, either partially or fully, by a thrombus.:357
Fusiform aneurysms ("spindle-shaped" aneurysms) are variable in both their diameter and length; their diameters can extend up to 20 cm (7.9 in). They often involve large portions of the ascending and transverse aortic arch, the abdominal aorta, or less frequently the iliac arteries.:357
Aneurysms can also be classified by their location:
- Arterial and venous, with arterial being more common.
- The heart, including coronary artery aneurysms, ventricular aneurysms, aneurysm of sinus of Valsalva, and aneurysms following cardiac surgery.
- The aorta, namely aortic aneurysms including thoracic aortic aneurysms and abdominal aortic aneurysms.
- The brain, including cerebral aneurysms, berry aneurysms, and Charcot–Bouchard aneurysms.
- The legs, including the popliteal arteries.
- The kidney, including renal artery aneurysm and intraparechymal aneurysms.
- Capillaries, specifically capillary aneurysms.
Cerebral aneurysms, also known as intracranial or brain aneurysms, occur most commonly in the anterior cerebral artery, which is part of the circle of Willis. This can cause severe strokes leading to death. The next most common sites of cerebral aneurysm occurrence are in the internal carotid artery.
|>2.0 cm and <3.0 cm|
|Moderate||3.0 - 5.0 cm|
|Large or severe||>5.0 or 5.5 cm|
Abdominal aortic aneurysms are commonly divided according to their size and symptomatology. An aneurysm is usually defined as an outer aortic diameter over 3 cm (normal diameter of the aorta is around 2 cm), or more than 50% of normal diameter that of a healthy individual of the same sex and age. If the outer diameter exceeds 5.5 cm, the aneurysm is considered to be large.
|Normal||Diameter ≤12 mm|
|Ectatic||Diameter 12 to 18 mm|
|Aneurysm||Diameter ≥18 mm|
Signs and symptomsEdit
Symptoms can occur when the aneurysm pushes on a structure in the brain. Symptoms will depend on whether an aneurysm has ruptured or not. There may be no symptoms present at all until the aneurysm ruptures. For an aneurysm that has not ruptured the following symptoms can occur:
- Loss of perception
- Loss of balance
- Speech problems
- Double vision
For a ruptured aneurysm, symptoms of a subarachnoid hemorrhage may present:
- Severe headaches
- Loss of vision
- Double vision
- Neck pain or stiffness
- Pain above or behind the eyes
Abdominal aortic aneurysm involves a regional dilation of the aorta and is diagnosed using ultrasonography, computed tomography, or magnetic resonance imaging. A segment of the aorta that is found to be greater than 50% larger than that of a healthy individual of the same sex and age is considered aneurysmal. Abdominal aneurysms are usually asymptomatic but in rare cases can cause lower back pain or lower limb ischemia.
Renal (kidney) aneurysmEdit
- Flank pain and tenderness
- Signs of hypovolemic shock
Specific infective causes associated with aneurysm include:
- Advanced syphilis infection resulting in syphilitic aortitis and an aortic aneurysm
- Tuberculosis, causing Rasmussen's aneurysms
- Brain infections, causing infectious intracranial aneurysms
A minority of aneurysms are associated with genetic factors. Examples include:
Aneurysms form for a variety of interacting reasons. Multiple factors, including factors affecting a blood vessel wall and the blood through the vessel, contribute.
Atherosclerosis. A variety of different factors, including atherosclerosis, may contribute to weakening of a blood vessel wall. The repeated trauma of blood flowing through the vessel may contribute to degeneration[clarification needed] of the vessel wall. Hypertensive injury may compound this degeneration and accelerate the expansion of the aneurysm. As the aneurysm expands, the wall tension increases.
The pressure of blood within the expanding aneurysm may also injure the blood vessels supplying the artery itself, further weakening the vessel wall. Without treatment, these aneurysms will ultimately progress and rupture.
Infection. A mycotic aneurysm is an aneurysm that results from an infectious process that involves the arterial wall. A person with a mycotic aneurysm has a bacterial infection in the wall of an artery, resulting in the formation of an aneurysm. The most common locations include arteries in the abdomen, thigh, neck, and arm. A mycotic aneurysm can result in sepsis, or life-threatening bleeding if the aneurysm ruptures. Less than 3% of abdominal aortic aneurysms are mycotic aneurysms.
Copper deficiency. A minority of aneurysms are caused by copper deficiency, which results in a decreased activity of the lysyl oxidase enzyme, affecting elastin, a key component in vessel walls. Copper deficiency results in vessel wall thinning, and thus has been noted as a cause of death in copper-deficient humans, chickens and turkeys
Aneurysmal blood vessels are prone to rupture under normal blood pressure and flow due to their special mechanical properties that make them weaker. To better understand this phenomenon, we can first look at healthy arterial vessels which exhibit a J-shaped stress-strain curve with high strength and high toughness (for a biomaterial in vivo). Unlike crystalline materials whose linear elastic region follows Hooke’s Law under uniaxial loading, many biomaterials exhibit a J-shaped stress-strain curve which is non-linear and concave up. The blood vessel can be under large strain, or the amount of stretch the blood vessel can undergo, for a range of low applied stress before fracture, as shown by the lower part of the curve. The area under the curve up to a given strain is much lower than that for the equivalent Hookean curve, which is correlated to toughness. Toughness is defined as the amount of energy per unit volume a material can absorb before rupturing. Because the amount of energy release is proportional to the amount of crack propagation, the blood vessel wall can withstand pressure and is “tough.” Thus, healthy blood vessels with the mechanical properties of the J-shaped stress-strain curve have greater stability against aneurysms than materials with linear elasticity.
Blood vessels with aneurysms, on the other hand, are under the influence of an S-shaped stress-strain curve. As a visual aid, aneurysms can be understood as a long, cylindrical balloon. Because it’s a tight balloon under pressure, it can pop at any time a stress beyond a certain force threshold is applied. In the same vein, an unhealthy blood vessel has elastic instabilities that lead to rupture. Initially, for a given radius and pressure, stiffness of the material increases linearly. At a certain point, the stiffness of the arterial wall starts to decrease with increasing load. At higher strain values, the area under the curve increases, thus increasing the impact on the material that would promote crack propagation. The differences in the mechanical properties of the aneurysmal blood vessels and the healthy blood vessels stem from the compositional differences of the vessels. Compared to normal aortas, aneurysmal aortas have a much higher volume fraction of collagen and ground substance (54.8% vs. 95.6%) and a much lower volume fraction of elastin (22.7% vs. 2.4%) and smooth muscles (22.6% vs. 2.2%), which contribute to higher initial stiffness. It was also found that the ultimate tensile strength, or the strength to withstand rupture, of aneurysmal vessel wall is 50% lower than that of normal aortas. The wall strength of ruptured aneurysmal aortic wall was also found to be 54.2 N/cm2, which is much lower than that of a repaired aorta wall, 82.3 N/cm2. Due to the change in composition of the arterial wall, aneurysms overall have much lower strength to resist rupture. Predicting the risk of rupture is difficult due to the regional anisotropy the hardened blood vessels exhibit, meaning that the stress and strength values vary depending on the region and the direction of the vessel they are measured along.
Diagnosis of a ruptured cerebral aneurysm is commonly made by finding signs of subarachnoid hemorrhage on a computed tomography (CT) scan. If the CT scan is negative but a ruptured aneurysm is still suspected based on clinical findings, a lumbar puncture can be performed to detect blood in the cerebrospinal fluid. Computed tomography angiography (CTA) is an alternative to traditional angiography and can be performed without the need for arterial catheterization. This test combines a regular CT scan with a contrast dye injected into a vein. Once the dye is injected into a vein, it travels to the cerebral arteries, and images are created using a CT scan. These images show exactly how blood flows into the brain arteries.
Historically, the treatment of arterial aneurysms has been limited to either surgical intervention, or watchful waiting in combination with control of blood pressure. At least, in case of Abdominal Aortic Aneurysm (AAA) the decision does not come without a significant risk and cost, hence, there is a great interest in identifying more advanced decision making approaches that are not solely based on the AAA diameter, but involve other geometrical and mechanical nuances such as local thickness and wall stress. In recent years,[when?] endovascular or minimally invasive techniques have been developed for many types of aneurysms. Aneurysm clips are used for surgical procedure i.e. clipping of aneurysms.
There are currently two treatment options for brain aneurysms: surgical clipping or endovascular coiling. There is currently debate in the medical literature about which treatment is most appropriate given particular situations.
Surgical clipping was introduced by Walter Dandy of the Johns Hopkins Hospital in 1937. It consists of a craniotomy to expose the aneurysm and closing the base or neck of the aneurysm with a clip. The surgical technique has been modified and improved over the years.
Endovascular coiling was introduced by Italian neurosurgeon Guido Guglielmi at UCLA in 1989. It consists of passing a catheter into the femoral artery in the groin, through the aorta, into the brain arteries, and finally into the aneurysm itself. Platinum coils initiate a clotting reaction within the aneurysm that, if successful, fills the aneurysm dome and prevents its rupture. Flow diverter can be used but not without complications sometimes.
Aortic and peripheral aneurysmsEdit
For aneurysms in the aorta, arms, legs, or head, the weakened section of the vessel may be replaced by a bypass graft that is sutured at the vascular stumps. Instead of sewing, the graft tube ends, made rigid and expandable by nitinol wireframe, can be easily inserted in its reduced diameter into the vascular stumps and then expanded up to the most appropriate diameter and permanently fixed there by external ligature. New devices were recently developed to substitute the external ligature by expandable ring allowing use in acute ascending aorta dissection, providing airtight (i.e. not dependent on the coagulation integrity), easy and quick anastomosis extended to the arch concavity Less invasive endovascular techniques allow covered metallic stent grafts to be inserted through the arteries of the leg and deployed across the aneurysm.
Renal aneurysms are very rare consisting of only 0.1–0.09% while rupture is even more rare. Conservative treatment with control of concomitant hypertension being the primary option with aneurysms smaller than 3 cm. If symptoms occur, or enlargement of the aneurysm, then endovascular or open repair should be considered. Pregnant women (due to high rupture risk of up to 80%) should be treated surgically.
Incidence rates of cranial aneurysms are estimated at between 0.4% and 3.6%. Those without risk factors have expected prevalence of 2–3%.:181 In adults, females are more likely to have aneurysms. They are most prevalent in people ages 35 – 60, but can occur in children as well. Aneurysms are rare in children with a reported prevalence of .5% to 4.6%. The most common incidence are among 50-year-olds, and there are typically no warning signs. Most aneurysms develop after the age of 40.
Incidence rates are two to three times higher in males, while there are more large and giant aneurysms and fewer multiple aneurysms.:235 Intracranial hemorrhages are 1.6 times more likely to be due to aneurysms than cerebral arteriovenous malformations in whites, but four times less in certain Asian populations.:235
Most patients, particularly infants, present with subarachnoid hemorrhage and corresponding headaches or neurological deficits. The mortality rate for pediatric aneurysms is lower than in adults.:235
Modeling of aneurysms consists of creating a 3D model that mimics a particular aneurysm. Using patient data for the blood velocity, and blood pressure, along with the geometry of the aneurysm, researchers can apply computational fluid dynamics (CFD) to predict whether an aneurysm is benign or if it is at risk of complication. One risk is rupture. Analyzing the velocity and pressure profiles of the blood flow leads to obtaining the resulting wall shear stress on the vessel and aneurysm wall. The neck of the aneurysm is the most at risk due to the combination of a small wall thickness and high wall shear stress. When the wall shear stress reaches its limit, the aneurysm ruptures, leading to intracranial hemorrhage. Conversely, another risk of aneurysms is the creation of clots. Aneurysms create a pocket which diverts blood flow. This diverted blood flow creates a vortex inside of the aneurysm. This vortex can lead to areas inside of the aneurysm where the blood flow is stagnant, which promotes formations of clots. Blood clots can dislodge from the aneurysm, which can then lead to an embolism when the clot gets stuck and disrupts blood flow. Model analysis allows these risky aneurysms to be identified and treated.
In the past, aneurysms were modeled as rigid spheres with linear inlets and outlets.As technology advances, the ability to detect and analyze aneurysms becomes easier. Researchers are able to CT scan a patient's body to create a 3D computer model that possesses the correct geometry. Aneurysms can now be modeled with their distinctive "balloon" shape. Nowadays researchers are optimizing the parameters required to accurately model a patient's aneurysm that will lead to a successful intervention. Current modeling is not able to take into account all variables though. For example, blood is considered to be a non-Newtonian fluid. Some researchers treat blood as a Newtonian fluid instead, as it sometimes has negligible effects to the analysis in large vessels. When analyzing small vessels though, such as those present in intracranial aneurysms. Similarly, sometimes it is difficult to model the varying wall thickness in small vessels, so researchers treat wall thickness as constant. Researchers make these assumptions to reduce computational time. Nonetheless, making erroneous assumptions could lead to a misdiagnosis that could put a patient's life at risk.
- Lucille Ball, who died from an aortic rupture in the abdominal area days after having undergone apparently successful heart surgery for a dissecting aortic aneurysm
- Laura Branigan, who died of a cerebral aneurysm
- David Cone, who suffered from an aneurysm and missed most of the 1996 baseball season
- John Olerud, suffered an aneurysm in 1989 and forced to wear batting helmet on field all of his career since then
- Albert Einstein, who died from a repaired aortic aneurysm
- Thomas Mikal Ford, who died from a ruptured aneurysm in his abdomen. He was 52.
- Charles de Gaulle, who died from an aneurysm within his neck
- Richard Holbrooke, who died from a thoracic aortic aneurysm
- Stuart Sutcliffe, who died from an aneurysm in his brain's right hemisphere
- John Ritter, died September 11, 2003 of a misdiagnosed thoracic aortic dissection (aortic aneurysm).
- Isabel Granada, who died of a cerebral aneurysm
- Geoffrey Thompson, who died of a brain aneurysm at his daughter's wedding, hosted at his theme park, Blackpool Pleasure Beach.
- Edwin Rosario died of an aneurysm in 1997.
- "Aneurysms". Society of NeuroInterventional Surgery. Retrieved 2018-02-23.
- Cronenwett JL, Murphy TF, Zelenock GB, Whitehouse WM, Lindenauer SM, Graham LM, Quint LE, Silver TM, Stanley JC (September 1985). "Actuarial analysis of variables associated with rupture of small abdominal aortic aneurysms". Surgery. 98 (3): 472–83. PMID 3898453.
- Kumar V, ed. (2007). Robbins basic pathology (8th ed.). Philadelphia: Saunders/Elsevier.
- Baird RJ, Doran ML (August 1964). "THE FALSE ANEURYSM". Canadian Medical Association Journal. 91: 281–4. PMC 1927240. PMID 14180533.
- Norwood MG, Lloyd GM, Moore S, Patel N, Panditi S, Sayers RD (April 2004). "The changing face of femoral artery false aneurysms". European Journal of Vascular and Endovascular Surgery. 27 (4): 385–8. doi:10.1016/j.ejvs.2004.01.001. PMID 15015188.
- Li JW, Wang SM, Chen XD (August 2004). "Management of femoral artery pseudoaneurysm due to addictive drug injection". Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi. 7 (4): 244–6. PMID 15294105.
- Currie S, Mankad K, Goddard A (January 2011). "Endovascular treatment of intracranial aneurysms: review of current practice". Postgraduate Medical Journal. 87 (1023): 41–50. doi:10.1136/pgmj.2010.105387. PMID 20937736.
- Azar D, Ohadi D, Rachev A, Eberth JF, Uline MJ, Shazly T (February 2018). "Mechanical and geometrical determinants of wall stress in abdominal aortic aneurysms: A computational study". PLOS ONE. 13 (2): e0192032. doi:10.1371/journal.pone.0192032. PMC 5798825. PMID 29401512.
- Anastasiou I, Katafigiotis I, Pournaras C, Fragkiadis E, Leotsakos I, Mitropoulos D, Constantinides CA (2013). "A Cough Deteriorating Gross Hematuria: A Clinical Sign of a Forthcoming Life-Threatening Rupture of an Intraparenchymal Aneurysm of Renal Artery (Wunderlich's Syndrome)". Case Reports in Vascular Medicine. 2013: 452317. doi:10.1155/2013/452317. PMC 3705747. PMID 23864981.
- Christianto B. Lumenta, ed. (2010). Neurosurgery. Heidelberg: Springer. p. 181. ISBN 978-3-540-79564-3.
- Lumb, Philip (2014-01-16). Critical Care Ultrasound E-Book. ISBN 9780323278171. Archived from the original on 2017-09-08. Retrieved 2017-08-23. Page 56] in: Philip Lumb (2014). Critical Care Ultrasound E-Book. Elsevier Health Sciences. ISBN 9780323278171.
- Lindholt JS, Juul S, Fasting H, Henneberg EW (April 2005). "Screening for abdominal aortic aneurysms: single centre randomised controlled trial". BMJ. 330 (7494): 750. doi:10.1136/bmj.38369.620162.82. PMC 555873. PMID 15757960.
- Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL, et al. (September 2006). "ACC/AHA Guidelines for the Management of Patients with Peripheral Arterial Disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Associations for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (writing committee to develop guidelines for the management of patients with peripheral arterial disease)--summary of recommendations". Journal of Vascular and Interventional Radiology. 17 (9): 1383–97, quiz 1398. doi:10.1097/01.RVI.0000240426.53079.46. PMID 16990459.
- Kent KC (November 2014). "Clinical practice. Abdominal aortic aneurysms". The New England Journal of Medicine. 371 (22): 2101–8. doi:10.1056/NEJMcp1401430. PMID 25427112.
- Melissa L Kirkwood. "Iliac artery aneurysm". Retrieved 2018-02-23. Last updated: Mar 27, 2017.
- Walker BR, Colledge NR, Ralston SH (2010). Davidson's principles and practice of medicine (21st ed.). Edinburgh: Churchill Livingstone/Elsevier. p. 604. ISBN 978-0-7020-3085-7.
- Manasco, Hunter. "The Aphasias". Introduction to Neurogenic Communication Disorders. p. 93.
- Schueler SJ, Beckett JH, Gettings DS (August 18, 2010). "Berry Aneurysm in the Brain". freemd. Archived from the original on March 12, 2016. Retrieved November 13, 2011.
- as described by the Law of Laplace
- Juvela S, Porras M, Poussa K (May 2008). "Natural history of unruptured intracranial aneurysms: probability of and risk factors for aneurysm rupture". Journal of Neurosurgery. 108 (5): 1052–60. doi:10.3171/JNS/2008/108/5/1052. PMID 18447733.
- emedicine – Cerebral Aneurysm Author: Jonathan L Brisman. Coauthors: Emad Soliman, Abraham Kader, Norvin Perez. Updated: Sep 23, 2010
- Schueler SJ, Beckett JH, Gettings S (November 13, 2011). "Mycotic Aneurysm". Archived from the original on March 12, 2016. Retrieved November 13, 2012.
- Paulo N, Cascarejo J, Vouga L (February 2012). "Syphilitic aneurysm of the ascending aorta". Interactive Cardiovascular and Thoracic Surgery. 14 (2): 223–5. doi:10.1093/icvts/ivr067. PMC 3279976. PMID 22159251.
- Mäki J (2002). Lysyl oxidases : cloning and characterization of the fourth and the fifth human lysyl oxidase isoenzymes, and the consequences of a targeted inactivaton of the first described lysyl oxidase isoenzyme in mice (PDF). Oulu: Oulun yliopisto. ISBN 951-42-6739-7.
- Rucker RB, Kosonen T, Clegg MS, Mitchell AE, Rucker BR, Uriu-Hare JY, Keen CL (May 1998). "Copper, lysyl oxidase, and extracellular matrix protein cross-linking". The American Journal of Clinical Nutrition. 67 (5 Suppl): 996S–1002S. doi:10.1093/ajcn/67.5.996S. PMID 9587142.
- Smith-Mungo LI, Kagan HM (February 1998). "Lysyl oxidase: properties, regulation and multiple functions in biology". Matrix Biology. 16 (7): 387–98. doi:10.1016/s0945-053x(98)90012-9. PMID 9524359.
- Senapati A, Carlsson LK, Fletcher CD, Browse NL, Thompson RP (May 1985). "Is tissue copper deficiency associated with aortic aneurysms?". The British Journal of Surgery. 72 (5): 352–3. doi:10.1002/bjs.1800720507. PMID 3995240.
- Tilson MD (September 1982). "Decreased hepatic copper levels. A possible chemical marker for the pathogenesis of aortic aneurysms in man". Archives of Surgery. 117 (9): 1212–3. doi:10.1001/archsurg.1982.01380330070017. PMID 7202350.
- Guenthner E, Carlson CW, Emerick RJ (September 1978). "Copper salts for growth stimulation and alleviation of aortic rupture losses in turkeys". Poultry Science. 57 (5): 1313–24. doi:10.3382/ps.0571313. PMID 724600.
- "DoITPoMS - TLP Library Elasticity in Biological Materials". www.doitpoms.ac.uk. Retrieved 2019-05-24.
- He, Chang M.; Roach, Margot R. (July 1994). "The composition and mechanical properties of abdominal aortic aneurysms". Journal of Vascular Surgery. 20 (1): 6–13. doi:10.1016/0741-5214(94)90169-4. PMID 8028090.
- Vorp, David A.; Geest, Jonathan P. Vande (August 2005). "Biomechanical Determinants of Abdominal Aortic Aneurysm Rupture". Arteriosclerosis, Thrombosis, and Vascular Biology. 25 (8): 1558–1566. doi:10.1161/01.ATV.0000174129.77391.55. ISSN 1079-5642.
- J. Thubrikar, M. Labrosse, F. Robic, M. (January 2001). "Mechanical properties of abdominal aortic aneurysm wall". Journal of Medical Engineering & Technology. 25 (4): 133–142. doi:10.1080/03091900110057806. ISSN 0309-1902.CS1 maint: multiple names: authors list (link)
- "Aneurysm Clip". Surgical Units.
- Raja PV, Huang J, Germanwala AV, Gailloud P, Murphy KP, Tamargo RJ (June 2008). "Microsurgical clipping and endovascular coiling of intracranial aneurysms: a critical review of the literature". Neurosurgery. 62 (6): 1187–202, discussion 1202–3. doi:10.1227/01.neu.0000333291.67362.0b. PMID 18824986.
- Guglielmi G (September 2007). "History of endovascular endosaccular occlusion of brain aneurysms: 1965-1990". Interventional Neuroradiology. 13 (3): 217–24. doi:10.1177/159101990701300301. PMC 3345485. PMID 20566113.
- Lv X, Yang H, Liu P, Li Y (February 2016). "Flow-diverter devices in the treatment of intracranial aneurysms: A meta-analysis and systematic review". The Neuroradiology Journal. 29 (1): 66–71. doi:10.1177/1971400915621321. PMC 4978339. PMID 26838174.
- Nazari, S. (2010). "sp.html". Interactive Cardiovascular and Thoracic Surgery. Fondazionecarrel.org. 10 (2): 161–4. doi:10.1510/icvts.2009.216291. PMID 19933306. Retrieved 2014-05-30.
- Aluffi A, Berti A, Buniva P, Rescigno G, Nazari S (2002). "Improved device for sutureless aortic anastomosis applied in a case of cancer". Texas Heart Institute Journal. 29 (1): 56–9. PMC 101273. PMID 11995854.
- Nazari S (February 2010). "Expandable device type III for easy and reliable approximation of dissection layers in sutureless aortic anastomosis. Ex vivo experimental study". Interactive Cardiovascular and Thoracic Surgery. 10 (2): 161–4. doi:10.1510/icvts.2009.216291. PMID 19933306.
- Stefano Nazari. "Expandable device type III for easy and reliable approximation of dissection layers in sutureless aortic anastomosis. Ex vivo experimental study". Icvts.ctsnetjournals.org. Archived from the original on 2011-09-30. Retrieved 2014-05-30.
- Nazari, S. (2010). "ndicvts.html". Interactive Cardiovascular and Thoracic Surgery. Fondazionecarrel.org. 10 (2): 161–4. doi:10.1510/icvts.2009.216291. PMID 19933306. Retrieved 2014-05-30.
- Schorn B, Falk V, Dalichau H, et al. (1997). "Kidney salvage in a case of ruptured renal artery aneurysm: case report and literature review". Cardiovasc Surg. 5 (1): 134–136. doi:10.1016/s0967-2109(95)00041-0.
- Tham G, Ekelund L, Herrlin K, Lindstedt EL, Olin T, Bergentz SE (March 1983). "Renal artery aneurysms. Natural history and prognosis". Annals of Surgery. 197 (3): 348–52. doi:10.1097/00000658-198303000-00016. PMC 1352740. PMID 6830341.
- Uflacker R. Interventional management of visceral artery aneurysms. In: Strandness DE, ed. Vascular Diseases: Surgical & Interventional Therapy. New York, NY: Churchill Livingstone; 1994:823–844.
- Lumsden AB, Salam TA, Walton KG (1996). "Renal artery an?eurysm: a report of 28 cases". Cardiovasc Surg. 4 (2): 185–189. doi:10.1016/0967-2109(96)82312-X.
- "Brain Aneurysm Basics | The Brain Aneurysm Foundation". Bafound.org. Archived from the original on 2014-05-30. Retrieved 2014-05-30.
- Nabong, Jennica Rica; David, Guido (October 2017). "Finite element model of size, shape and blood pressure on rupture of intracranial saccular aneurysms". Journal of Physics: Conference Series. 893: 012054. doi:10.1088/1742-6596/893/1/012054. ISSN 1742-6596.
- Algabri, Y. A.; Rookkapan, S.; Chatpun, S. (September 2017). "Three-dimensional finite volume modelling of blood flow in simulated angular neck abdominal aortic aneurysm". IOP Conference Series: Materials Science and Engineering. 243: 012003. doi:10.1088/1757-899X/243/1/012003. ISSN 1757-899X.
- Sarrami-Foroushani, Ali; Lassila, Toni; Hejazi, Seyed Mostafa; Nagaraja, Sanjoy; Bacon, Andrew; Frangi, Alejandro F. (2019-06-25). "A computational model for prediction of clot platelet content in flow-diverted intracranial aneurysms". Journal of Biomechanics. 91: 7–13. doi:10.1016/j.jbiomech.2019.04.045. ISSN 0021-9290.
- Zhong, Liang; Zhang, Jun-Mei; Su, Boyang; Tan, Ru San; Allen, John C.; Kassab, Ghassan S. (2018-06-26). "Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities". Frontiers in Physiology. 9. doi:10.3389/fphys.2018.00742. ISSN 1664-042X. PMC 6028770. PMID 29997520.
- Liepsch, D.; Sindeev, S.; Frolov, S. (August 2018). "An impact of non-Newtonian blood viscosity on hemodynamics in a patient-specific model of a cerebral aneurysm". Journal of Physics: Conference Series. 1084: 012001. doi:10.1088/1742-6596/1084/1/012001. ISSN 1742-6596.
- Thenier-Villa, José Luis; Riveiro Rodríguez, Antonio; Martínez-Rolán, Rosa María; Gelabert-González, Miguel; González-Vargas, Pedro Miguel; Galarraga Campoverde, Raúl Alejandro; Díaz Molina, Jorge; De La Lama Zaragoza, Adolfo; Martínez-Cueto, Pedro; Pou, Juan; Conde Alonso, Cesáreo (2018-10-01). "Hemodynamic Changes in the Treatment of Multiple Intracranial Aneurysms: A Computational Fluid Dynamics Study". World Neurosurgery. 118: e631–e638. doi:10.1016/j.wneu.2018.07.009. ISSN 1878-8750.
- Sforza, Daniel M.; Putman, Christopher M.; Cebral, Juan R. (June 2012). "Computational fluid dynamics in brain aneurysms". International journal for numerical methods in biomedical engineering. 28 (0): 801–808. doi:10.1002/cnm.1481. ISSN 2040-7939. PMC 4221804. PMID 25364852.
- Ball L (April 27, 1989). "Lucy dies". Chicago Tribune. Retrieved May 12, 2013.
- "Article: Lucille Ball, Pioneer of Television Comedy, Dies at 77". Archived from the original on November 6, 2012. Retrieved August 31, 2009.
- Ball L (April 27, 1989). "Ball dies of ruptured aorta". Los Angeles Times. Retrieved May 12, 2013.
- "Dr. Albert Einstein Dies in Sleep at 76; World Mourns Loss of Great Scientist". The New York Times. April 19, 1955.
- "World Leaders to Gather in Paris to Honour General de Gaulle". The Times. 11 November 1970.
- "US Diplomat Holbrooke dies after tearing arota".
- Wright J (9 April 2012). "Stuart Sutcliffe: Legacy of the fifth Beatle 50 years after his death". Echo.
- Considine B (February 4, 2008). "John Ritter's widow talks about wrongful death suit". today.com.
- "John Ritter: 1948–2003". people.com. September 18, 2003. p. 2.
- Roxas, Patricia Ann (25 October 2017). "Report: Isabel Granada in coma in Qatar hospital". Inquirer.net. Retrieved 25 October 2017.
- ALG (5 November 2017). "Isabel Granada passes away in Qatar". GMA News. Retrieved 5 November 2017.
|Wikimedia Commons has media related to Aneurysms.|
|Look up aneurysm in Wiktionary, the free dictionary.|
- @neurIST – Integrated Biomedical Informatics for the Management of Cerebral Aneurysms
- Brain aneurysm and percent packing calculator