The main informant about Anchiale was Strabo. According to Strabo the city had been constructed by Sardanapalus, the last king of Assyria. Strabo further claims that Sardanapalus' tomb is in Anchiale. The city was conquered by Alexander the Great just before the battle of Issus.
The exact location of Anchiale is debatable. Like most historians British captain Francis Beaufort identifies Anchiale with Karaduvar, now a neighbourhood of Mersin at . But he adds that the amount of ruins in Karaduvar are too few for an important ancient city.