In the late 2nd century BC, along with the fellow Cimbri and Teutons, the Ambrones migrated from their original homes and invaded the Roman Republic, winning a spectacular victory at the Battle of Arausio in 105 BC. The Ambrones and the Teutons, led by Teutobod, were eventually defeated at the Battle of Aquae Sextiae in 102 BC.
The exact location of the homeland of the Ambrones is unknown. Their name has been connected to the islands of Fehmarn, old name Imbria, and Amrum. If so they may be the Ymbers of Widsith. However the inundation of the Wadden Sea region during this period suggests that they lived west of Jutland, not east of Jutland. The river Emmer, formerly Ambriuna, has also been mentioned as their place of origin.
The three neighbors began their career in Roman history as an alliance determined to emigrate to the lands of the south. A Roman source reports that "The Cimbri, Teutones and Tigurini, fugitives from the extreme parts of Gaul, since the Ocean had inundated their territories, began to seek new settlement throughout the world." The Zuider Zee region was suffering from catastrophic salt-water flooding; this section of seacoast had been barely above sea level during the BCE period of human history, but was now in the process of sinking below it.
The Ambrones were part of the fleeing multitude. Plutarch gives the numbers advancing on Italy as 300,000 armed fighting men, and much larger hordes of women and children. (Many of Plutarch's figures were enormous exaggerations). The Barbarians divided themselves into two bands, and it fell to the lot of the Cimbri to proceed through Noricum in the interior of the country against Catulus, and of a passage there, while the Teutones and Ambrones were to march through Liguria along the sea-coast against the consul Gaius Marius, who had set up camp on the Rhône. Plutarch tells us that Ambrones alone numbered more than 30,000 and were the most warlike division of the enemy, who had earlier defeated the Romans under Gnaeus Mallius Maximus and Quintus Servilius Caepio. The Ambrones followed a custom observed amongst Celts in the shouting the name of their tribe going into battle. It was the Battle of Arausio in 105 in which the Romans were defeated under Servilius Caepio and Gnaeus Mallius.
The Teutones and Ambrones assaulted the camp of Marius and were repulsed. They decided to go on and streamed around the camp, giving the Roman soldiers messages for the wives they should encounter as domestics when enslaved. Marius followed swiftly and again encamped next to them at Aquae Sextiae at the foot of the Alps. The year was 102 BC.
The battle began as a chance encounter but the Romans turned it into a victory. Roman camp followers attempting to draw water from a nearby river were attacked by the Ambrones, who were still using it. The Ligurians acting as Roman auxiliaries came to their rescue and were repulsed across the river. The opportunity was not lost on Marius. The Romans quickly formed ranks and caught the Ambrones trying to recross the river. The Ambrones lost the main part of their force. Two days later Marius repulsed an attack on the camp and caught the enemy force between his own main force in the front and an ambush of 3,000 men in the enemy rear. Plutarch reported that Marius took 100,000 prisoners, though this is likely exaggerated.  Some of the surviving captives are reported to have been among the rebelling Gladiators in the Third Servile War. Although Caesar mentions that the remnants of the Cimbri and Teutones formed a new tribe in Belgic Gaul, the Aduatuci, he does not mention any remnants of the Ambrones.
- Hussey, Joan Mervyn (1957). The Cambridge Medieval History. CUP Archive. pp. 191–193.
It was the Cimbri, along with their allies the Teutones and Ambrones, who for half a score of years kept the world in suspense. All three peoples were doubtless of Germanic stock. We may take it as established that the original home of the Cimbri was on the Jutish peninsula, that of the Teutones somewhere between the Ems and the Weser, and that of the Ambrones in the same neighborhood, also on the North Sea coast.
- "History of Europe". Encyclopædia Britannica Online. Retrieved June 26, 2018.
Even before 200 bce the first Germanic tribes had reached the lower Danube, where their path was barred by the Macedonian kingdom. Driven by rising floodwaters, at the end of the 2nd century bce, migratory hordes of Cimbri, Teutoni, and Ambrones from Jutland broke through the Celtic-Illyrian zone and reached the edge of the Roman sphere of influence, appearing first in Carinthia (113 bce), then in southern France, and finally in upper Italy.
- Lucius Annaeus Florus, The Epitome of Roman History, book I, part 38.
- Plutarch, Lives: Life of Marius.
- Livy, Periochae, book 67.
- Plutarch, Lives: Life of Marius; Livy, Periochae, book 68.
- Plutarch, Lives: Life of Marius.
- Strauss, Barry (2009). The Spartacus War. Simon and Schuster. pp. 21–22. ISBN 1-4165-3205-6.
- Caesar, Gallic War, book 2, chapter 29.