The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.[5]

AliasesATP8B3, ATPIK, ATPase phospholipid transporting 8B3
External IDsMGI: 1914581 HomoloGene: 19034 GeneCards: ATP8B3
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ATP8B3
Genomic location for ATP8B3
Band19p13.3Start1,782,075 bp[1]
End1,812,276 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 1.78 – 1.81 MbChr 10: 80.52 – 80.54 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130270 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003341 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: ATPase, aminophospholipid transporter, class I, type 8B, member 3". Retrieved 2011-10-22.

External linksEdit

Further readingEdit

  • Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (November 1999). "Differential expression of putative transbilayer amphipath transporters". Physiological Genomics. 1 (3): 139–50. PMID 11015572.
  • Harris MJ, Arias IM (July 2003). "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body". Biochimica et Biophysica Acta. 1633 (2): 127–31. doi:10.1016/S1388-1981(03)00107-0. PMID 12880872.
  • Fries AS, Svendsen O (January 1978). "Studies on Tyzzer's disease in rats". Laboratory Animals. 12 (1): 1–4. PMID 146761.
  • Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M (May 2009). "Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 106 (18): 7501–6. doi:10.1073/pnas.0813386106. PMC 2678639. PMID 19416921.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.