V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.[5][6]

AliasesATP6V1D, ATP6M, VATD, VMA8, ATPase H+ transporting V1 subunit D
External IDsMGI: 1921084 HomoloGene: 5783 GeneCards: ATP6V1D
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for ATP6V1D
Genomic location for ATP6V1D
Band14q23.3Start67,294,371 bp[1]
End67,360,265 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 14: 67.29 – 67.36 MbChr 12: 78.84 – 78.86 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100554 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021114 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annu Rev Cell Dev Biol. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
  6. ^ a b "Entrez Gene: ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D".

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