V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.[5][6]

ATP6V0D1
Identifiers
AliasesATP6V0D1, ATP6D, ATP6DV, P39, VATX, VMA6, VPATPD, ATPase H+ transporting V0 subunit d1
External IDsMGI: 1201778 HomoloGene: 3444 GeneCards: ATP6V0D1
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for ATP6V0D1
Genomic location for ATP6V0D1
Band16q22.1Start67,438,014 bp[1]
End67,481,181 bp[1]
RNA expression pattern
PBB GE ATP6V0D1 212041 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004691

NM_013477

RefSeq (protein)

NP_004682

NP_038505

Location (UCSC)Chr 16: 67.44 – 67.48 MbChr 8: 105.52 – 105.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159720 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013160 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ van Hille B, Vanek M, Richener H, Green JR, Bilbe G (Jan 1994). "Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase". Biochem Biophys Res Commun. 197 (1): 15–21. doi:10.1006/bbrc.1993.2434. PMID 8250920.
  6. ^ a b "Entrez Gene: ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1".

External linksEdit

Further readingEdit