Renin receptor

  (Redirected from ATP6AP2)

The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.[5][6][7]

Available structures
PDBOrtholog search: PDBe RCSB
AliasesATP6AP2, APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028, ATPase H+ transporting accessory protein 2
External IDsOMIM: 300556 MGI: 1917745 HomoloGene: 38097 GeneCards: ATP6AP2
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for ATP6AP2
Genomic location for ATP6AP2
BandXp11.4Start40,579,372 bp[1]
End40,606,848 bp[1]
RNA expression pattern
PBB GE ATP6AP2 201444 s at fs.png

PBB GE ATP6AP2 201443 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 40.58 – 40.61 MbChr X: 12.59 – 12.62 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse


The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.[8]

This protein is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182220 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031007 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572.
  6. ^ Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID 11590366.
  7. ^ a b "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".
  8. ^ Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. doi:10.1172/JCI14276. PMC 150992. PMID 12045255.

Further readingEdit

External linksEdit