ATP synthase subunit e, mitochondrial is an enzyme that in humans is encoded by the ATP5ME gene.[3][4]

ATP5ME
Identifiers
AliasesATP5ME, ATP5K, ATP synthase, H+ transporting, mitochondrial Fo complex subunit E, ATP synthase membrane subunit e, ATP5I
External IDsHomoloGene: 136813 GeneCards: ATP5ME
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ATP5ME
Genomic location for ATP5ME
Band4p16.3Start672,436 bp[1]
End674,330 bp[1]
RNA expression pattern
PBB GE ATP5I 207335 x at fs.png

PBB GE ATP5I 209492 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007100

n/a

RefSeq (protein)

NP_009031

n/a

Location (UCSC)Chr 4: 0.67 – 0.67 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human
ATP synthase E chain
Identifiers
SymbolATP-synt_E
PfamPF05680
InterProIPR008386
SCOPe1e79
SUPERFAMILY1e79

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex.[4]

In yeast, the FO complex E subunit appears to play an important role in supporting F-ATPase dimerisation. This subunit is anchored to the inner mitochondrial membrane via its N-terminal region, which is involved in stabilising subunits G and K of the FO complex. The C-terminal region of subunit E is hydrophilic, protruding into the intermembrane space where it can also help stabilise the F-ATPase dimer complex.[5]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169020 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Swartz DA, Park EI, Visek WJ, Kaput J (Oct 1996). "The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation". J Biol Chem. 271 (34): 20942–8. doi:10.1074/jbc.271.34.20942. PMID 8702853.
  4. ^ a b "Entrez Gene: ATP5ME ATP synthase membrane subunit e".
  5. ^ Everard-Gigot V, Dunn CD, Dolan BM, Brunner S, Jensen RE, Stuart RA (February 2005). "Functional analysis of subunit e of the F1Fo-ATP synthase of the yeast Saccharomyces cerevisiae: importance of the N-terminal membrane anchor region". Eukaryotic Cell. 4 (2): 346–55. doi:10.1128/EC.4.2.346-355.2005. PMC 549337. PMID 15701797.

External linksEdit

Further readingEdit


This article incorporates text from the public domain Pfam and InterPro: IPR008386