The ATP5MC2 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.[5][6]

ATP5MC2
Identifiers
AliasesATP5MC2, ATP5A, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9), ATP synthase membrane subunit c locus 2, ATP5G2
External IDsMGI: 1915192 HomoloGene: 57052 GeneCards: ATP5MC2
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ATP5MC2
Genomic location for ATP5MC2
Band12q13.13Start53,632,726 bp[1]
End53,677,408 bp[1]
RNA expression pattern
PBB GE ATP5G2 208764 s at fs.png

PBB GE ATP5G2 207552 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002031
NM_005176
NM_001330269

NM_026468

RefSeq (protein)

NP_001002031
NP_001317198
NP_005167

NP_080744

Location (UCSC)Chr 12: 53.63 – 53.68 MbChr 15: 102.66 – 102.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135390 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062683 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Dyer MR, Walker JE (Aug 1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase". Biochem J. 293 (1): 51–64. doi:10.1042/bj2930051. PMC 1134319. PMID 8328972.
  6. ^ a b "Entrez Gene: ATP5MC2 ATP synthase membrane subunit c locus 2".

External linksEdit

Further readingEdit