The ATP5MC1 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.[5][6]

ATP5MC1
Identifiers
AliasesATP5MC1, ATP5A, ATP5G, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9), ATP synthase membrane subunit c locus 1, ATP5G1
External IDsMGI: 107653 HomoloGene: 38017 GeneCards: ATP5MC1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ATP5MC1
Genomic location for ATP5MC1
Band17q21.32Start48,892,765 bp[1]
End48,895,871 bp[1]
RNA expression pattern
PBB GE ATP5G1 208972 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005175
NM_001002027

NM_001161419
NM_007506

RefSeq (protein)

NP_001002027
NP_005166

NP_001154891
NP_031532

Location (UCSC)Chr 17: 48.89 – 48.9 MbChr 11: 96.07 – 96.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Contents

FunctionEdit

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159199 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006057 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Dyer MR, Walker JE (Jul 1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase". The Biochemical Journal. 293 (Pt 1): 51–64. doi:10.1042/bj2930051. PMC 1134319. PMID 8328972.
  6. ^ a b "Entrez Gene: ATP5MC1 ATP synthase membrane subunit c locus 1".

External linksEdit

Further readingEdit