Plasma membrane calcium-transporting ATPase 3 is an enzyme that in humans is encoded by the ATP2B3 gene.[5][6]

AliasesATP2B3, CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1, ATPase plasma membrane Ca2+ transporting 3
External IDsMGI: 1347353 HomoloGene: 123775 GeneCards: ATP2B3
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for ATP2B3
Genomic location for ATP2B3
BandXq28Start153,517,676 bp[1]
End153,582,939 bp[1]
RNA expression pattern
PBB GE ATP2B3 207026 s at fs.png

PBB GE ATP2B3 215911 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 153.52 – 153.58 MbChr X: 73.5 – 73.57 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067842 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031376 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Wang MG, Yi H, Hilfiker H, Carafoli E, Strehler EE, McBride OW (Jun 1994). "Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26→p25 and Xq28, respectively". Cytogenet Cell Genet. 67 (1): 41–5. doi:10.1159/000133794. PMID 8187550.
  6. ^ a b "Entrez Gene: ATP2B3 ATPase, Ca++ transporting, plasma membrane 3".

External linksEdit

Further readingEdit