Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.[5][6]

AliasesATP2A3, SERCA3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
External IDsMGI: 1194503 HomoloGene: 69131 GeneCards: ATP2A3
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ATP2A3
Genomic location for ATP2A3
Band17p13.2Start3,923,870 bp[1]
End3,964,464 bp[1]
RNA expression pattern
PBB GE ATP2A3 207521 s at fs.png

PBB GE ATP2A3 213036 x at fs.png

PBB GE ATP2A3 207522 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 17: 3.92 – 3.96 MbChr 11: 72.96 – 72.99 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

This gene encodes one of the SERCA Ca2+-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in cardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.[6]



ATP2A3 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. [7] For this reason, ATP2A3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. [7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000074370 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020788 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R (Nov 1996). "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene". Biochem J. 318 (2): 689–99. PMC 1217674. PMID 8809064.
  6. ^ a b "Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous".
  7. ^ a b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1001/jamadermatol.2018.1373. PMID 25205602.

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