ATP2A2 is an ATPase associated with Darier's disease and Acrokeratosis verruciformis.

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Identifiers
SymbolATP2A2
Alt. symbolsATP2B, DAR
Entrez488
HUGO812
OMIM108740
RefSeqNM_001681
UniProtP16615
Other data
EC number3.6.3.8
LocusChr. 12 q23-q24

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells.[1] This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.

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