Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.[5]

ATP1B1
Identifiers
AliasesATP1B1, ATP1B, ATPase Na+/K+ transporting subunit beta 1
External IDsMGI: 88108 HomoloGene: 37509 GeneCards: ATP1B1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ATP1B1
Genomic location for ATP1B1
Band1q24.2Start169,105,697 bp[1]
End169,132,722 bp[1]
RNA expression pattern
PBB GE ATP1B1 201242 s at fs.png

PBB GE ATP1B1 201243 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001677
NM_001001787

NM_009721

RefSeq (protein)

NP_001668

NP_033851

Location (UCSC)Chr 1: 169.11 – 169.13 MbChr 1: 164.44 – 164.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143153 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026576 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide".

Further readingEdit

External linksEdit