2001 in South Africa
- 18 – The Department of Health declines the offer of a large donation of HIV test kits made by Guardian Scientific Africa Incorporated.
- 5 – George Bizos is awarded the 2001 International Trial Lawyer Prize of the Year by the International Academy of Trial Lawyers.
- 11 – Pfizer Inc. agrees to supply AIDS patients attending public hospitals with an unlimited two-year supply of Fluconazole.
- 30 – South Africa and India sign a declaration of intent on co-operation in health and medicine.
- 11 – The Maloti-Drakensberg Transfrontier Conservation Area is signed into existence.
- 12–15 – President Thabo Mbeki undertakes a state visit to the United Kingdom.
- 4 – The first 40 of a planned 1000 elephants, including 3 breeding herds, are translocated from the over-populated Kruger National Park to the war-ravaged Limpopo National Park.
- 9 – The second South African National Census takes place.
- The name of the Gaza-Kruger-Gonarezhou Transfrontier Park is changed to the Great Limpopo Transfrontier Park.
- 4 – Marike de Klerk, ex-wife of former State President Frederik Willem de Klerk, is murdered in her flat in Bloubergrant.
- Unknown date
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- 26 April – Frederick Guy Butler, poet, academic and writer (b. 1918)
- 1 June – Nkosi Johnson, HIV/AIDS activist. (b. 1989)
- 13 August – Fanie du Plessis, athlete. (b. 1930)
- 19 August – Donald Woods, journalist and activist. (b. 1933)
- 30 August – Govan Mbeki, South African political activist and the father of Thabo Mbeki. (b. 1910)
- 2 September – Christiaan Barnard, cardiac surgeon. (b. 1922)
- 4 December – Marike de Klerk, former first lady. (b. 1941)
- Archontology.org: A Guide for Study of Historical Offices: South Africa: Heads of State: 1994-2017 (Accessed on 5 June 2017)
- Middleton, John N. (2002). Railways of Southern Africa Locomotive Guide - 2002 (as amended by Combined Amendment List 4, January 2009) (2nd, Dec 2002 ed.). Herts, England: Beyer-Garratt Publications. pp. 50, 61.